Testosterone Cypionate
Testosterone Cypionate

Army Pharma Lab Testosterone Cypionate Injection,250mg/mlINDICATIONS AND USAGETestosterone Cypionate 250mgInjection is indicated for replacement therapy inthe male in conditions associated with symptomsof deficiency or absence of endogenoustestosterone.1. Primary hypogonadism (congenital oracquired)-testicular failure due tocryptorchidism, bilateral torsion, orchitisvanishing testis syndrome; or orchidectomy2. Hypogonadotropic hypogonadism(congenital or acquired) -idiopathicgonadotropin or LHRH deficiency, or pituitary-hypothalamic injuryfrom tumors, trauma, or radiation.CONTRA INDICATIONS1. Known hypersensitivity to the drug2. Males with carcinoma of the breast3. Males with known or suspected carcinoma ofthe prostate gland4. Women who are or who may becomepregnant5. Patients with serious cardiac, hepatic or renaldiseaseWARNINGSHypercalcemia mayoccur in immobilized patientsIf this occurs, the drug should be discontinued.Prolonged use of high doses of androgens(principally the 17-a alkyl-androgens) has beenassociated with development of hepaticadenomas, hepatocellular carcinoma, andpeliosis hepatis —all potentially life-threateningcomplications.Geriatric patients treated withandrogens maybe at an increased risk ofdeveloping prostatic hypertrophyand prostatic carcinoma although conclusiveevidence to support this concept is lacking.There have been postmarketing reports ofvenous thromboembolic events, including deepvein thrombosis (DVT) and pulmonary embolism(PE), in patients using testosterone products,such as testosterone cypionate.Evaluate patients who report symptoms of pain,edema, warmth and erythema in the lowerextremity for DVT and those who present withacute shortness of breath for PE. If a venousthromboembolic event is suspected,discontinue treatment with testosteronecypionate and initiate appropriate workup andmanagement.Edema, with or without congestiveheart failure, maybe a serious complication inpatients with pre-existing cardiac, renal orhepatic disease. Gynecomastia may developand occasionally persists in patients beingtreated for hypogonadism.This product contains benzyl alcohol. Benzylalcohol has been reported to be associated witha fatal “Gasping Syndrome” in premature infants.Androgen therapy should be used cautiously inhealthy males with delayed puberty. The effecton bone maturation should be monitored byassessing bone age of the wrist and hand every6 months. In children, androgen treatment mayaccelerate bone maturation without producingcompensatory gain in linear growth. Thisadverse effect may result in compromisedadultstature. The younger the child the greaterthe risk of compromising final mature height.This drug has not been shown to be safe andeffective for the enhancement of athleticperformance. Because of the potential risk ofserious adverse health effects, this drugshould not be used for such purpose.PRECAUTIONSGeneralPatients with benign prostatic hypertrophymay develop acute urethral obstruction.Priapism or excessive sexual stimulation maydevelop. Oligospermia may occur afterprolonged administration or excessive dosage.

If any of these effects appear, the androgenshould be stopped and if restarteda lower dosage should be utilized.Testosterone cypionate should not be usedinterchangeably with testosterone propionatebecause of differences in duration of action.Testosterone cypionate is not for intravenous use.Information for patientsPatients should be instructed to report any of thefollowing: nausea, vomiting, changes inskin color, ankle swelling, too frequent orpersistent erections of the penis.Laboratory testsHemoglobin and hematocrit levels (to detectpolycythemia) should be checked periodically inpatients receiving long-term androgenadministration.Serum cholesterol may increase during androgentherapy.Drug interactionsAndrogens may increase sensitivity to oralanticoagulants. Dosage of the anticoagulant mayrequire reduction in order to maintain satisfactorytherapeutic hypoprot hrombinemia.Concurrent administration of oxyphenbutazoneand androgens may result in elevated serumlevels of oxyphenbutazone. In diabetic patients,the metabolic effects of androgens may decreaseblood glucose and, therefore, insulinrequirements.Drug/Laboratory test InterferencesAndrogens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4serum levels and increased resin uptake of T3and T4. Free thyroid hormone levels remainunchanged, however, and there is no clinicalevidence of thyroid dysfunction.Nursing mothersArmy Pharma Lab Testosterone is notrecommended for use in nursing mothers.OVERDOSAGEThere have been no reports of acute overdosagewith the androgens.DOSAGE AND ADMINISTRATIONTestosterone Injection is for intramuscularuse only.It should not be given intravenously. Intramuscularinjections should be given deep in the glutealmuscle. The suggested dosage for ARMYTestosterone Injection varies depending on theage, sex, and diagnosis of the individual patient.Dosage is adjusted according to the patient’sresponse and the appearance of adversereactions.Various dosage regimens have been used toinduce pubertal changes in hypogonadal males;some experts have advocated lower dosagesinitially, gradually increasing thedose as puberty progresses, with or without adecrease to maintenance levels. Other expertsemphasize that higher dosages are neededto induce pubertal changes and lowerdosages can be used for maintenance afterpuberty.

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